Specifications

1. lyophilization
2. white powder
3. agonist of GnRH receptor
4. API
5. high quality

  Triptorelin is a decapeptide drug derived from gonadotrophin releasing hormone (GnRH) by the replacement of Gly6 with D- tryptophan in the amino acid sequence. Triptorelin is an agonist of GnRH receptor with higher potency and longer plasma half-life compared with its natural counterpart. After injection, Triptorelin stimulates putative to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), while the causing constant stimulation of putative leads it into refractory period that  reduces the release of Gonadotrophin and thus results in the sex steroid (testosterone or estrogen) to emasculation level. Furthermore, the above physiological process is reversible.

  In clinical, Triptorelin is used for the treatment of the hormone-responsive conditions by lowering the sex steroid hormones in serum to the emasculation level. For instance, it has been applied for medication of androgen-dependent prostatic cancer; endometriosis, fibroid and assisted reproduction.

  Triptorelin has been marketed in many countries. Beyel Pharmaceuticals is capable of manufacturing the drug API Triptorelin Acetate under GMP compliance.

 Essential information

Molecular formula: C₆₄H₈₂N₁₈O₁₃

Molecular weight: 1311.46

Amino acid sequence:

Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂

 Quality standard

1,Appearance: white powder

2,Water content (Karl Fischer): ≤8%

3,Acetate content (HPLC method): ≤10%

4,Amino acid composition: ±10% theoretical value

5,Purity (by two HPLC methods): ≥98.0%

6,Single impurity (by two HPLC methods): ≤1.0%

7,Total impurity (by two HPLC methods): ≤2%

8,Peptide content (Kjeldahl method): ≥80%

9,Assay (anhydrous, without acetate): 95%-105%

10,Bacterial endotoxins: ≤5EU/mg

Pack: plastic bottle (peptide special) or glass vial

Short-term storage: avoid from moisture and light at 2-8°C

Long-term storage: avoid from moisture and light at -20°C

Period of validity: 2.0 years

Changchun BCHT Biotechnology Co.

Basic Information

Business Type:

Main Products: Varicella Vaccine Live,Rabies Vaccine(Vero cell)for human use

Location:

Total Employees: 501 - 1000 People

Year Established: 2004

Trade Information

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Overseas Office: No

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